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UNIT 1 GENERAL PRINCIPLES OF TOXICOLOGY 1

1 History and Scope of Toxicology&Michael A.Gallo 3

2 Principles of Toxicology&David L.Eaton and Curtis D.Klaassen 11

3 Mechanisms of Toxicity&Zoltán Gregus and Curtis D.Klaassen 35

4 Risk Assessment&Elaine M.Faustman and Gilbert S.Omenn 83

UNIT 2 DISPOSITION OF TOXICANTS 105

5 Absorption,Distribution,and Excretion of Toxicants&Karl K.Rozman and Curtis D.Klaassen 107

6 Biotransformation of Xenobiotics&Andrew Parkinson 133

7 Toxicokinetics&Michele A.Medinsky and John L.Valentine 225

UNIT 3 NON-ORGAN-DIRECTED TOXICITY 239

8 Chemical Carcinogenesis&Henry C.Pitot Ⅲ and Yvonne P.Dragan 241

9 Genetic Toxicology&R.Julian Preston and George R.Hoffmann 321

10 Developmental Toxicology&John M.Rogers and Robert J.Kavlock 351

UNIT 4 TARGET ORGAN TOXICITY 387

11 Toxic Responses of the Blood&John C.Bloom and John T.Brandt 389

12 Toxic Responses of the Immune System&Leigh Ann Burns-Naas,B.Jean Meade,and Albert E.Munson 419

13 Toxic Responses of the Liver&Mary Treinen-Moslen 471

14 Toxic Responses of the Kidney&Rick G.Schnellmann 491

15 Toxic Responses of the Respiratory System&Hanspeter R.Witschi and Jerold A.Last 515

16 Toxic Responses of the Nervous System&Douglas C.Anthony,Thomas J.Montine,William M.Valentine and Doyle G.Graham 535

17 Toxic Responses of the Ocular and Visual System&Donald A.Fox and William K.Boyes 565

18 Toxic Responses of the Heart and Vascular Systems&Kenneth S.Ramos,Russell B.Melchert,Enrique Chacon and Daniel Acosta,Jr 597

19 Toxic Responses of the Skin&David E.Cohen and Robert H.Rice 653

20 Toxic Responses of the Reproductive System&Michael J.Thomas and John A.Thomas 673

21 Toxic Responses of the Endocrine System&Charles C.Capen 711

UNIT 5 TOXIC AGENTS 761

22 Toxic Effects of Pesticides&Donald J.Ecobichon 763

23 Toxic Effects of Metals&Robert A.Goyer and Thomas W.Clarkson 811

24 Toxic Effects of Solvents and Vapors&James V.Brucknerand D.Alan Warren 869

25 Toxic Effects of Radiation and Radioactive Materials&Naomi H.Harley 917

26 Toxic Effects of Terrestrial Animal Venoms and Poisons&Findlay E.Russell 945

27 Toxic Effects of Plants&Stata Norton 965

UNIT 6 ENVIRONMENTAL TOXICOLOGY 977

28 Air Pollution&Daniel L.Costa 979

29 Ecotoxicology&Ronald J.Kendall,Todd A.Anderson,Robert J.Baker,Catherine M.Bens,James A.Carr,Louis A.Chiodo,George P.Cobb Ⅲ,Richard L.Dickerson,Kenneth R.Dixon,Lynn T.Frame,Michael J.Hooper,Clyde F.Martin,Scott T.McMurry,Reynaldo Patino,Ernest E.Smith,Christopher W.Theodorakis 1013

UNIT 7 APPLICATIONS OF TOXICOLOGY 1047

30 Food Toxicology&Frank N.Kotsonis,George A.Burdock,and W.Gary Flamm 1049

31 Analytic/Forensic Toxicology&Alphonse Poklis 1089

32 Clinical Toxicology&Louis R.Cantilena,Jr 1109

33 Occupational Toxicology&Peter S.Thorne 1123

34 Regulatory Toxicology&Richard A.Merrill 1141

Appendix:Recommended Limits for Occupational Exposure to Chemicals&John Doull 1155

Index 1177