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第一部分 奋斗历程 1

我的科研历程 3

天然来源的抗肿瘤药物研究与开发的典范 9

第二部分 学术贡献 15

一、甄永苏院士的主要学术论文 17

五种抗肿瘤药物对小鼠各种组织损害作用的比较 17

N-甲酰溶肉瘤素对小鼠精原细胞的损害作用 26

小鼠各种组织细胞对N-甲酰溶肉瘤素敏感性的比较——病理形态和细胞计数的研究 34

The Murine Spermatogonial Depletion Assay as A Method for Primary Screening of Antitumour Substances 41

抗肿瘤药物初筛方法——精原细胞法和噬菌体法的比较研究 53

争光霉素A5和争光霉素A2的抗肿瘤作用与毒性研究 61

Dexamethasone Synergistically Induces Chemotactic Peptide Receptor Expression in HL-60 Cells 69

A Human Granulocyte-Specific Antigen Characterized by Use of Monoclonal Antibodies 79

Effects of Acivicin and Dipyridamole on Hepatoma 3924A Cells 88

Amphotericin B Renders Stationary Phase Hepatoma Cells Sensitive to Dipyridamole 94

抗CCT2单克隆抗体和争光霉素A6结合物的抗白血病细胞活性 98

博来霉素A6抗人体肝癌的实验研究 102

Amphotericin B: A Biological Response Modifier in Targeting Against the Salvage Pathways 107

A New Macromolecular Antitumor Antibiotic, C-1027 Ⅲ. Antitumor Activity 114

Potentiation of Antimetabolite Antitumor Activity in Vivo by Dipyridamole and Amphotericin B 119

Mode of Action of C-1027, A New Macromolecular Antitumor Antibiotic With Highly Potent Cytotoxicity, on Human Hepatoma BEL-7402 Cells 127

博来霉素A6对小鼠肺毒性的电子显微镜观察 136

Green Tea Extract Inhibits Nucleoside Transport and Potentiates the Antitumor Effect of Antimetabolites 141

Azidothymidine and Dipyridamole as Biochemical Response Modifiers: Synergism with Methotrexate and 5-Fluorouracil in Human Colon and Pancreatic Carcinoma Cells 148

Antitumor Activity of Immunoconjugates Composed of Boanmycin and Monoclonal Antibody 156

Novel Nucleoside Transport Inhibitors of Natural Origin 162

A Single Binding Mode of Activated Enediyne C1027 Generates Two Types of Double-Strand DNA Lesions: Deuterium Isotope-Induced Shuttling Between Adjacent Nucleotide Target Sites 164

Antibiotic C3368-A, A Fungus-Derived Nucleoside Transport Inhibitor, Potentiates the Activity of Antitumor Drugs 179

Induction of Apoptosis by Enediyne Antitumor Antibiotic C1027 in HL-60 Human Promyelocytic Leukemia Cells 186

Antitumor Activity of Yunnanmycin A Novel Pyrimidine Nucleoside Antibiotic 191

Antitumor Components From an Actinomycete Strain 6011W 195

Cinnamamide, an Antitumor Agent With Low Cytotoxicity Acting on Matrix Metalloproteinase 199

Intracellular Expression of A Single-Chain Antibody Directed Against Type Ⅳ Collagenase Inhibits the Growth of Lung Cancer Xenografts in Nude Mice 204

Activity of Boanmycin Against Colorectal Cancer 210

大黄素抑制人高转移巨细胞肺癌PG细胞的肿瘤转移相关性质 217

Antitumor Effects of Monoclonal Antibody Fab′ Fragment-Containing Immunoconj ugates 224

Antitumor Effects of the Molecule-Downsized Immunoconjugate Composed of Lidamycin and Fab′ Fragment of Monoclonal Antibody Directed Against Type Ⅳ Collagenase 230

HERG K+ Channel Expression-Related Chemosensitivity in Cancer Cells and Its Modulation by Erythromycin 239

An Enediyne-Energized Single-Domain Antibody-Containing Fusion Protein Shows Potent Antitumor Activity 250

Down-Regulation of the Nuclear Factor-kB by Lidamycin in Association With Inducing Apoptosis in Human Pancreatic Cancer Cells and Inhibiting Xenograft Growth 263

Synergy of Gemcitabine and Lidamycin Associated With NF-kB Downregulation in Pancreatic Carcinoma Cells 272

Binding Capability of the Enediyne-Associated Apoprotein to Human Tumors and Constitution of A Ligand Oligopeptide-Integrated Protein 279

Enediyne Lidamycin Enhances the Effect of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Gefitinib, in Epidermoid Carcinoma A431 Cells and Lung Carcinoma H460 Cells 291

Lidamycin Shows Highly Potent Cytotoxic to Myeloma Cells and Inhibits Tumor Growth in Mice 301

Rhein Lysinate Suppresses the Growth of Breast Cancer Cells and Potentiates the Inhibitory Effect of Taxol in Athymic Mice 310

A Bispecific Enediyne-Energized Fusion Protein Containing Ligand-Based and Antibody-Based Oligopeptides Against Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 Shows Potent Antitumor Activity 319

A Tandem ScFv-Based Fusion Protein and Its Enediyne-Energized Analogue Show Intensified Therapeutic Efficacy Against Lung Carcinoma Xenograft in Athymic Mice 331

Endostar, A Modified Recombinant Human Endostatin, Exhibits Synergistic Effects With Dexamethasone on Angiogenesis and Hepatoma Growth 343

Antitumor Efficacy of the scFv-Based Fusion Protein and Its Enediyne-Energized Analogue Directed Against Epidermal Growth Factor Receptor 354

Pingyangmycin Downregulates the Expression of EGFR and Enhances the Effects of Cetuximab on Esophageal Cancer Cells and the Xenograft in Athymic Mice 366

An NGR-Integrated and Enediyne-Energized Apoprotein Shows CD13-Targeting Antitumor Activity 377

Lidamycin Inhibits Tumor Growth and Pulmonary Metastasis in Murine Breast Carcinoma and Shows Synergy With Paclitaxel 387

抗肿瘤导向药物研究的现状与展望 396

天然来源的新型抗肿瘤生化调节剂 405

抗肿瘤抗生素和治疗肿瘤的单克隆抗体药物 408

抗体药物靶向治疗肿瘤前景广阔 419

抗肿瘤抗生素平阳霉素研究与临床应用40年 423

二、甄永苏院士的主要学术著作 429

TEA 429

抗体工程药物 446

抗体药物研究与应用 464

抗肿瘤药物研究与开发 475

三、甄永苏院士学术年表 520

个人简历 520

甄永苏院士论文目录 521

甄永苏院士参加的主要学术会议与报告 540

甄永苏院士著作目录 546

甄永苏院士培养研究生名录 548

甄永苏院士已获授权的专利项目 553

第三部分 治学之道 557

科技创新的认识与实践 559

勤奋 敬业 乐群 562

沙里淘金费苦辛 药中奥妙细追寻——记中国工程院院士甄永苏教授 565

甄永苏：科研贵在创新 567

第四部分 大师风范 571

甄永苏院士——我们的良师益友 573

写在甄永苏院士从业60周年前夕 576

在甄永苏老师身边学习和工作的日子 580

在甄老师身边多年的一些感悟 582

回忆甄老师指导我如何作好科研报告 584

我认识的甄老师 586

在院士身边做博士 588

尊敬的师长，真正的大师 590

与甄永苏院士的师生缘 592

桃李芬芳引路人 青丝华发闪师恩 593

上善若水，大爱无痕 594

第五部分 人生风采 597

美满家庭 599

校友情深 602

学科建设 604

学术活动 606

国际交流 609

重要时刻 611

院士活动 613