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第一部分 奋斗历程 1

侯凡凡院士简历 3

第二部分 学术贡献 7

一、侯凡凡院士的学术成就与学术思想 9

二、侯凡凡院士的主要学术论文 13

（一）临床研究论文 13

Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency 13

Renoprotection of Optimal Antiproteinuric Doses （ROAD） Study：A Randomized Controlled Study of Benazepril and Losartan in Chronic Renal Insufficiency 23

Urinary Angiotensinogen Level Predicts Acute Kidney Injury in Acute Decompensated Heart Failure：a Prospective，Two-Stage Study 34

Enhanced Expression of Receptor for Advanced Glycation End Products in Chronic Kidney Disease 49

Receptor for Advanced Glycation End Products on Human Synovial Fibroblasts：Role in the Pathogenesis of Dialysis-Related Amyloidosis 58

Accumulation of Tissue Advanced Glycation End Products Correlated with Glucose Exposure Dose and Associated with Cardiovascular Morbidity in Patients on Peritoneal Dialysis 70

Renal Expression of Advanced Oxidative Protein Products Predicts Progression of Renal Fibrosis in Patients with IgA Nephropathy 80

Metabolic Syndrome， but Not Insulin Resistance， is Associated with an Increased Risk of Renal Function Decline 93

High Level of Proteinuria During Treatment With Renin—Angiotensin Inhibitors Is A Strong Predictor of Renal Outcome in Nondiabetic Kidney Disease 102

Successful Treatment of Massive Ascites with Intraperitoneal Administration of a Steroid in a Case of Systemic Lupus Erythematosus 112

Increased Plasma Advanced Oxidation Protein Products is an Early Marker of Endothelial Dysfunction in Type 2 Diabetes Patients Without Albuminuria 115

（二）基础研究论文 124

Kindlin-2 Mediates Activation of TGF-β/Smad Signaling and Renal Fibrosis 124

A Salt-Induced Reno-Cerebral Reflex Activates RAS and Promotes CKD Progression 139

GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-Induced Smad3 Phosphorylation 166

Advanced Oxidation Protein Products Accelerate Renal Fibrosis in A Remnant Kidney Model 184

Aminoguanidine Inhibits Advanced Glycation End Products Formation on β2-Microglobulin 195

The Receptor of Advanced Glycation End Products Plays A Central Role In Advanced Oxidation Protein Products Induced Podocyte Apoptosis 202

Accumulation of Advanced Oxidation Protein Products Induces Podocyte Apoptosis and Deletion Through NADPH-Dependent Mechanisms 215

Restricted Intake of Dietary Advanced Glycation End Products Retards Renal Progression in the Remnant Kidney Model 231

β2-Microglobulin Modified with Advanced Glycation End Products Delays Monocyte Apoptosis 244

β2-Microglobulin Modified with Advanced Glycation End Products Modulates Collagen Synthesis by Human Fibroblasts 258

Interaction Between β2-Microglobulin and Advanced Glycation End Products in the Development of Dialysis Related- Amyloidosis 268

Advanced Oxidation Protein Products Activate Intrarenal Renin-Angiotensm System Via a CD36-Mediated， Redox-Dependent Pathway 275

Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via a RAGE-Mediated Signaling Pathway 294

Picrorhiza Scrophulariiflora Improves Accelerated Atherosclerosis Through Inhibition of Redox-Sensitive Inflammation 309

Lingzhiols，Unprecedented Rotary Door Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum 319

Acortatarins A and B， Two Novel Antioxidative Spiroalkaloids with A Naturally Unusual Morpholine Motif from Acorus Tatarinowii 324

Advanced Oxidation Protein Products Accelerate Atherosclerosis Through Promoting Oxidative Stress and Inflammation 329

AGE-LDL Activates Toll Like Receptor 4 Pathway and Promotes Inflammatory Cytokines Production in Renal Tubular Epithelial Cells 337

Salt-Induced Changes in Cardiac Phosphoproteome in a Rat Model of Chronic Renal Failure 350

Albumin Overload Activates Intrarenal Renin-Angiotensin System Through Protein Kinase C and NADPH Oxidasedependent Pathway 362

Bioactive Compounds from the Aerial Parts of Brachystemma Calycinum and Structural Revision of An Octacyclopeptide 375

Detection of Advanced Oxidation Protein Products in Patients with Chronic Kidney Disease by A Novel Monoclonal Antibody 386

Vascular Insulin Resistance Related to Endoplasmic Reticulum Stress in Aortas from a Rat Model of Chronic Kidney Disease 396

Advanced Oxidation Protein Products Inhibit Differentiation and Activate Inflammation in 3T3-Ll Preadipocytes 411

Advanced Oxidation Protein Products Induce Inflammatory Response and Insulin Resistance in Cultured Adipocytes Via Induction of Endoplasmic Reticulum Stress 422

Asymmetrical Dimethylarginine Triggers Lipolysis and Inflammatory Response Via Induction of Endoplasmic Reticulum Stress in Cultured Adipocytes 435

Advanced Oxidation Protein Products Induce Mesangial Cell Perturbation Through PKC-Dependent Activation of NADPH Oxidase 447

Ethanol Extraction of Picrorhiza Scrophulariiflora Prevents Renal Injury in Experimental Diabetes Via Anti-Inflammation Action 460

Advanced Oxidation Protein Products Promote Inflammation in Diabetic Kidney through Activation of Renal Nicotinamide Adenine Dinucleotide Phosphate Oxidase 470

1，25-Dihydroxyvitamin D Improved the Free Fatty-Acid-Induced Insulin Resistance in Cultured C2C12 Cells 483

Phenotypic and Functional Characteristics of Macrophage-Like Cells Differentiated in Pro-Inflammatory Cytokine-Containing Cultures 490

三、侯凡凡院士学术年表 500

侯凡凡院士在SCI收录期刊发表的社论和特邀述评 500

侯凡凡院士在SCI收录期刊发表的共同作者论著 501

侯凡凡院士承担的主要科研项目目录 503

侯凡凡院士主要国际会议演讲目录 504

第三部分 治学之道 507

努力作科学而不是努力作文章 509

凡凡女人心，不凡医者仁心路 511

漫漫行医路 浓浓鱼水情 514

循证医学可显著提高医疗卫生活动效率 519

第四部分 大师风范 521

医者仁心 师者爱心 学者恒心——记侯凡凡院士 523

第五部分 社会影响 527

不凡医者仁心路 529

最是那昂首的妩媚 530

走近女院士——侯凡凡 535

与病人交心才能确保治疗效果 537

我不认为我是大器晚成 539

既然当了医生，就得当位好医生 542

南方医院侯凡凡院士入选“全国医患和谐典型人物” 544

当医生就要把心交给患者 545

南方医院《关于开展向侯凡凡同志学习的决定》 548

病房没有关门，我就不能走远 550

技高为师 身正为范 552

第六部分 人生风采 555

成长经历 557

医疗科研 559

国际交流 564

历史时刻 567

幸福生活 569