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PartⅠ Fundamentals 3

1 Intellectual Property and Nanopharmaceuticals&Shivanand Puthli, Meenal S. Puthli, Ana Sofia Macedo, and Eliana B. Souto 3

2 Challenges and Emerging Issues in Patenting Nanomedicines&Rayasa S. Ramachandra Murthy 25

3 Legislative Measures for In Vitro-In Vivo Correlations and Pharmacokinetic Modeling&Viness Pillay, Yahya E. Choonara, Pradeep Kumar, Valence M.K. Ndesendo, and Lisa C. du Toit 49

Part Ⅱ Case Studies in Patenting Drug Delivery and Targeting Systems 99

4 Polymeric Nanoparticles, Magnetic Nanoparticles and Quantum Dots: Current and Future Perspectives&Javed Ali, Shadab Md, Sanjula Baboota, and Jasjeet K. Sahni 99

5 Sol-Gel Carrier System: A Novel Controlled Drug Delivery&Tatiana Andreani, Ana Luiza R. de Souza, Amelia M. Silva, and Eliana B. Souto 151

6 Nanomedicine and Brain Tumors Treatment&Gerardo Caruso, Mariella Caffo, Giuseppe Raudino, Chiara Tomasello, Concetta Alafaci, and Francesco Tomasello 167

7 Nanomedicine in Nucleic Acid Therapy&Anisha D'Souza, Sandhya Pranatharthiharan, and Padma V. Devarajan 205

8 Nanomedicines for Nasal Drug Delivery&Vikas Bali, Sumita Singh, and Ajay Kumar 251

9 Nanotechnology in Ophthalmic Drug Delivery&Ali A. A1-Kinani, Gianpiero Calabrese, Anil Vangala, Declan Naughton, and Raid G. Alany 277

10 Nanosized Drug Delivery for Enhancement of Oral Bioavailability&Mine Ozyazici, Evren Homan Gokce, and Aysu Yurdasiper 305

11 Chitosan and AIginate Nanoparticles as Oral Insulin Carrier&Tin Wui Wong, Uttamkumar Mandal, and Li-Jiuan Shen 345

12 Patenting Nanomedicines for Nutraceutical Ingredients&Prapapom Boonme 375

13 Nanomedicine in Dermatology: Benefits and Emerging Applications&Rosita Saraceno, Andrea Chiricozzi, Elisabetta Botti, Talia Gramiccia, Lucia Pietroleonardo, and Sergio Chimenti 383

14 Nanomedicine in Malaria&Kamalinder K. Singh 401

15 Nanomedicines for Immunization and Vaccines&Joana F. Fangueiro, Patricia Severino, Selma B. Souto, and Eliana B. Souto 435

Index 451