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PART Ⅰ BASICS OF MOLECULAR IMAGING AND NANOBIOTECHNOLOGY 3

1.Basic Principles of Molecular Imaging&Sven H.Hausner 3

2.Synthesis of Nanomaterials as a Platform for Molecular Imaging&Jinhao Gao，Jin Xie，Bing Xu，and Xiaoyuan Chen 25

3.Nanoparticle Surface Modification and Bioconjugation&Jin Xie，Jinhao Gao，Mark Michalski，and Xiaoyuan Chen 47

4.Biodistribution and Pharmacokinetics of Nanoprobes&Nagesh Kolishetti，Frank Alexis，Eric M.Pridgen，and Omid C.Farokhzad 75

PART Ⅱ NANOPARTICLES FOR SINGLE MODALITY MOLECULAR IMAGING 107

5.Computed Tomography as a Tool for Anatomical and Molecular Imaging&Pingyu Liu，Hu Zhou，and Lei Xing 107

6.Carbon Nanotube X-Ray for Dynamic Micro-CT Imaging of Small Animal Models&Otto Zhou，Guohua Cao，Yueh Z.Lee，and Jianping Lu 139

7.Quantum Dots for In Vivo Molecular Imaging&Yun Xing 159

8.Biopolymer，Dendrimer，and Liposome Nanoplatforms for Optical Molecular Imaging&David Pham，Ling Zhang，Bo Chen，and Ella Fung Jones 183

9.Nanoplatforms for Raman Molecular Imaging in Biological Systems&Zhuang Liu 197

10.Single-Walled Carbon Nanotube Near-Infrared Fluorescent Sensors for Biological Systems&Jingqing Zhang and Michael S.Strano 217

11.Microparticle- and Nanoparticle-Based Contrast-Enhanced Ultrasound Imaging&Nirupama Deshpande and Jurgen K.Willmann 233

12.Ultrasound-Based Molecular Imaging Using Nanoagents&Srivalleesha Mallidi，Mohammad Mehrmohammadi，Kimberly Homan，Bo Wang，Min Qu，Tmothy Larson，Konstantin Sokolov，and Stanislav Emelianov 263

13.MRI Contrast Agents Based on Inorganic Nanoparticles&Hyon Bin Na and Taeghwan Hyeon 279

14.Cellular Magnetic Labeling with Iron Oxide Nanoparticles&Sebastien Boutry，Sophie Laurent，Luce Vander Elst，and Robert N.Muller 309

15.Nanoparticles Containing Rare Earth Ions：A Tunable Tool for MRI&C.Riviere，S.Roux，R.Bazzi，J.-L.Bridot，C.Billotey，P.Perriat，and O.Tillement 333

16.Microfabricated Multispectral MRI Contrast Agents&Gary Zabow and Alan Koretsky 375

17.Radiolabeled Nanoplatforms：Imaging Hot Bullets Hitting Their Target&Raffaella Rossin 399

PART Ⅲ NANOPARTICLE PLATFORMS AS MULTIMODALITY IMAGING AND THERAPY AGENTS 433

18.Lipoprotein-Based Nanoplatforms for Cancer Molecular Imaging&Ian R.Corbin，Kenneth Ng，and Gang Zheng 433

19.Protein Cages as Multimode Imaging Agents&Masaki Uchida，Lars Liepold，Mark Young，and Trevor Douglas 463

20.Biomedical Applications of Single-Walled Carbon Nanotubes&Weibo Cai，Ting Gao，and Hao Hong 481

21.Multifunctional Nanoparticles for Multimodal Molecular Imaging&Yanglong Hou and Rui Hao 529

22.Multifunctional Nanoparticles for Cancer Theragnosis&Seulki Lee，Ick Chan Kwon，and Kwangmeyung Kim 541

23.Nanoparticles for Combined Cancer Imaging and Therapy&Vaishali Bagalkot，Mi Kyung Yu，and Sangyong Jon 565

24.Multimodal Imaging and Therapy with Magnetofluorescent Nanoparticles&Jason R.McCarthy and Ralph Weissleder 593

25.Gold Nanocages：A Multifunctional Platform for Molecular Optical Imaging and Photothermal Treatment&Leslie Au，Claire M.Cobley，Jingyi Chen，and Younan Xia 615

26.Theranostic Applications of Gold Nanoparticles in Cancer&Parmeswaran Diagaradjane，Pranshu Mohindra，and Sunil Krishnan 639

27.Gold Nanorods as Theranostic Agents&Alexander Wei，Qingshan Wei，and Alexei P.Leonov 659

28.Theranostic Applications of Gold Core-Shell Structured Nanoparticles&Wei Lu，Marites P.Melancon，and Chun Li 683

29.Magnetic Nanoparticle Carrier for Targeted Drug Delivery：Perspective，Outlook，and Design&R.D.K.Misra 709

30.Perfluorocarbon Nanoparticles：A Multidimensional Platform for Targeted Image-Guided Drug Delivery&Gregory M.Lanza，Shelton D.Caruthers，Anne H.Schmieder，Patrick M.Winter，Tillmann Cyrus，and Samuel A.Wickline 725

31.Radioimmunonanoparticles for Cancer Imaging and Therapy&Arutselvan Natarajan 755

PART Ⅳ TRANSLATIONAL NANOMEDICINE 783

32.Current Status and Future Prospects for Nanoparticle-Based Technology in Human Medicine&Nuria Sanvicens，Fatima Fernaindez，J.-Pablo Salvador，and M.-Pilar Marco 783

Index 815