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Introduction:Purpose and Scope of the Symposium＆BERNARD D．DAVIS 1

Part Ⅰ:The Origin of Enzymes＆Chairman:Bernard D．Davis 5

1．Remarks on the Mechanism of Enzyme Induction＆JACQUES MONOD 7

2．Enzymes in Cellular Differentiation＆BORIS EPHRUSSI 29

Added Comment＆MELVIN COHN 41

General Discussion＆BERNARD D．DAVIS,JACQUES MONOD,SOL SPIEGELMAN,CARL C．LINDEGREN,BORIS EPHRUSSI 46

3．Nucleic Acids and Enzyme Synthesis＆ERNEST F．GALE 49

4．On the Nature of the Enzyme-Forming System＆SOL SPIEGELMAN 67

Added Comment＆SIDNEY F．VELICK 90

General Discussion＆BERNARD D．DAVIS,SOL SPIEGELMAN,JACQUES MONOD,BORIS ROTMAN,ERNEST F．GALE,ARTHUR B．PARDEE,EDWARD L．TATUM,A．D．HERSHEY,MELVIN COHN,MAHLON B．HOAGLAND,ALVIN MARKOVITZ 93

Part Ⅱ:The Status of the Gene-Enzyme Relationship＆Chairman:Edward L．Tatum 105

Chairman＇s Comments＆EDWARD L．TATUM 107

5．Genetic Structure and Function in Bacteriophage T2＆A．D．HERSHEY 109

6．The Genetic Organization of the Deoxyribonucleate Units Functioning in Bacterial Transformations＆ROLLIN D．HOTCHKISS 119

Added comment＆M．DEMEREC 131

General Discussion＆NORMAN H．HOROWITZ,JACQUES MONOD,EDWARD L．TATUM,BERNARD D．DAVIS,CHARLES YANOFSKY,M．DEMEREC,A．D．HERSHEY,SOL SPIEGELMAN 134

7．The Role of the Genes in the Synthesis of Enzymes＆NORMAN H．HOROWITZ AND MARGUERITE FLING 139

8．Gene Interactions in Enzyme Synthesis＆CHARLES YANOFSKY 147

Comments on Gene-Enzyme Relationship＆JOSHUA LEDERBERG 161

General Discussion＆STUART MUDD,SOL SPIEGELMAN,RUTH SAGER,NORMAN H．HOROWITZ,EDWARD L．TATUM,ROBERT J．RUTMAN,HARRY EAGLE,CYRUS LEVINTHAL,NATHAN O．KAPLAN,JACQUES MONOD 170

Evening Lecture 175

The Future of Enzyme Research＆LINUS PAULING 177

Part Ⅲ:Enzymes and Cell Structure＆Chairman:George H．Hogeboom 183

9．Electron Microscopy of Mitochondria and Other Cytoplasmic Structures＆GEORGE E．PALADE 185

10．Physiology of Mitochondria＆ALBERT L．LEHNINGER 217

11．Sedimentation and Biochemical Characteristics of Cytoplasmic Particles＆EDWARD L．KUFF AND GEORGE H．HOGEBOOM 235

Added Comment＆VAN R．POTTER 252

General Discussion＆FRITZ LIPMANN,ALBERT L．LEHNINGER,DANIEL I．ARNON,HERRICK BALTSCHEFFSKY,BRITTON CHANCE,GEORGE E．PALADE 257

12．Nuclear Products and Nuclear Reproduction＆DANIEL MAZIA 261

13．Localization of Photosynthesis in Chloroplasts＆DANIEL I．ARNON 279

General Discussion＆CYRUS LEVINTHAL,DANIEL MAZIA,SEVERO OCHOA,DANIEL I．ARNON,NATHAN O．KAPLAN,VERNON CHELDELIN,GEORGE E．PALADE,HENRY A．LARDY,ALBERT L．LEHNINGER,DAVID E．GREEN,FRITZ LIPMANN 306

Part Ⅳ:Enzymatic Basis of Some Physiological Functions＆Chairman:A．Baird Hastings 315

14．The Actomyosin System and its Participation in Organized Enzyme Reactions＆W．F．H．M．MOMMAERTS 317

15．Is Energy Transferred from ATP to Myosin at the Moment that ATP is Split?＆MANUEL F．MORALES 325

16．Enzymatic Aspects of Excretory Mechanisms＆JOHN V．TAGGART 337

Added Comment＆GILBERT H．MUDGE 347

General Discussion＆A．BAIRD HASTINGS,JOHN GERGELY,MANUEL F．MORALES,W．F．H．M．MOMMAERTS,SIDNEY BERNHARD 349

17．The Biochemistry of Visual Excitation＆GEORGE WALD 355

18．The Enzymatic Basis of Light Emission＆WILLIAM D．MCELROY AND ARDA GREEN 369

Added Comment＆BERNARD L．STREHLER 381

General Discussion＆GEORGE WALD,MANUEL F．MORALES,WILLIAM D．MCELROY,W．F．H．M．MOMMAERTS,DANIEL I．ARNON,BERNARD L．STREHLER,J．J．WOLKEN 383

Evening Lecture 391

Mechano-chemical Coupling in Muscle＆ALBERT SZENT-GYORGYI 393

Part Ⅴ．Cellular Energy Sources＆Chairman:Fritz Lipmann 399

19．Components of the Cytochrome System＆ELMER H．STOTZ,MARTIN MORRISON,AND GUIDO MARINETTI 401

20．Succinic Dehydrogenase＆THOMAS P．SINGER,EDNA B．KEARNEY,AND VINCENT MASSEY 417

Added Comment＆ERIC G．BALL 433

General Discussion＆VAN R．POTTER,THOMAS P．SINGER,FRITZ LIPMANN,RICHARD J．WINZLER,HAROLD A．NEUFELD 440

Chairman＇s Comments＆FRITZ LIPMANN 444

21．Interaction of Adenosinediphosphate with the Respiratory Chain＆BRITTON CHANCE 447

22．Structural and Enzymatic Pattern of the Electron Transfer System＆DAVID E．GREEN 465

23．Hematin Compounds in the Metabolism of Photosynthetic Tissues＆MARTIN D．KAMEN 483

General Discussion＆W．F．H．M．MOMMAERTS,BRITTON CHANCE,DANIEL I．ARNON,FRITZ LIPMANN,DAVID E．GREEN,GEORGE E．PALADE,J．A．BASSHAM,MANUEL F．MORALES,ALVIN NASON,RALPH W．MCKEE,RONALD ESTABROOK,EDWARD L．TATUM 498

Part Ⅵ:Regulation of Enzyme activity＆Chairman:Severo Ochoa 505

Chairman＇s Comments 507

24．Relations between Enzymes and Permeability (Membrane Transport) in Bacteria＆BERNARD D．DAVIS 509

25．Action of Drugs on Enzyme Systems＆J．H．QUASTEL 523

Added Comment＆EARL W．SUTHERLAND,JR． 536

General Discussion＆SEVERO OCHOA,BERNARD D．DAVIS,CYRUS LEVINTHAL,JACQUES MONOD,STUART MUDD,OLOV LINDBERG,ARTHUR B．PARDEE 541

26．Interference with Nucleic Acid Metabolism＆ARNOLD D．WELCH 547

27．Regulation of Enzyme Activity in Muscle During Work＆CARL F．CORI 573

Added Comment＆HENRY A．LARDY AND R．E．PARKS,JR． 584

Chairman＇s Comments＆SEVERO OCHOA,ROBIN C．BUERKI 588

Author Index 589

Subject Index 604