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Part I: Development, Structure, and Function 1

1.Overview of the Respiratory System 3

Overall structure and function 3

The dvenamics of breathing 5

Control of breathing 5

Summary of respiratory functions 5

Preface 5

Acknowledgements 7

2.Organization of the Respiratory System 7

Upper respiratory tract 7

Dedication 10

Lower respiratory tract 13

Organization of the pulmonary circulation 22

Defence mechanisms of the Iungs 25

Metabolic functions of the Iungs 28

Ventilation 31

3.venfilatio and Gax Exchange 31

Mechanics of breathing 37

Dynamics of ventilation 47

Gaseous exchange in the Iungs 54

4.Perfusion and Gas Transport 59

pulmonary blood flow 59

The ventilation:perfusion relationship 67

Gas transport in the blood 72

Acid-base balance 80

5.Control of Respiratory function 87

Control of ventilation 87

Respiratory response to extreme environments 97

6.Pharrmacology of the respiratory System 103

Drugs and the respiratory system 103

Part II: Clinical Assessment 109

The history 111

7.Taking a History 111

Common presenting complaints 113

8.Examination of the Patient 125

General inspection 125

Hands and limbs 127

Head and neck 130

The thorax 135

9.Further Investigations 141

Investigations of respiratory function 141

Routine investigations 147

Imaging of the respiratory system 151

Part III: Basic Pathology 161

10.Pathology of the Upper Respiatory Tract 163

The nose and nasopharynx 163

The Iarynx 166

Congenital abnormalities 171

11.Pathology of the Lungs 171

Atelectasis 172

Vascular disease 173

Pulmonary disease 180

Infections of the Iung 189

Interstitial disease of the Iung 196

diseases of iatrogenic origin 202

Neoplastic disease of the Iung 204

Diseases of the pleura 211

Part IV: Self-assessment 215

MUltiple-choice Questions 217

Short-answer Questions 222

Essay Questions 223

MCQ Answers 224

SAQ Answers 225

Index 229