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Section I Basic Science 1

Dedication 3

1 Advances in the Study of Glial Lineage[Mark E. Linskey] 3

Special Dedication to Dr.Harry M.Zimmerman 5

Introduction 7

Contributors 9

2 The Actin-Cytoskeleton and Glial Cell Transformation: Dissecting the Molecular Dynamics of Tumorigenesis[Kenneth A. Giuliono] 35

3 The Fibrinolytic System in Human Brain Tumors: Association with Pathophysiological Conditions of Malignant Brain Tumors[Jasti S.Rao, Masaaki Yamamoto, Auoy K. Bindal, Weiming Shi, Shu Zhi Wu, and Raymond Sawaya] 49

4 Fibroblast Growth Factors in Astrocytomas[Richard S. Morrison, Shoko M.Yamada, and Yahua Yu] 69

5 Angiogenesis Inhibition in the Treatment of CNS Tumors[Allen K. Sills, Jr., Eric P. Sipos, John Laterra, and Henry Brem] 81

6 Protein Kinase C Inhibition, a Potential Therapeutic Strategy for Malignant Glial Tumors: A Summary of Preliminary Results and Future Directions[Ian F. Pollack, Pollack, Stephanie Kawecki, and John S. Lazo] 97

Section II Diagnosis 113

7 Imaging Update[Charles A. Jungreis and Carolyn Cidis Meltzer] 115

8 Molecular Neuropathology in Brain Tumor Diagnosis[Paul E. Mckeever] 139

Section III Therapy 179

9 Corticl Mapping in Tumor Resection[George A. Ojemann] 183

10 Ultrasonic Characteristics of Brain Tumors[George J. Dohrmann and Jonathan M. Rubin] 191

11 Intraoperative Neurophysiological Monitoring During Removal of Brain Tumors[Aage R. Moller] 207

12 Stereotactic Radiosurgery for Benign and Malignant Diseases of the Brain[Zbigniew Petrovich, Gary Luxton, Silvia C. Formenti, Chi-Shing Zee, Chang Yu, Gabor Jozsef, and Michael L. J. Apuzzo] 219

13 Surgery for Spinal Metastases[William C. Welch] 259

14 Radiobiology Update[James D. Kolker and Ralph R. Weichselbaum] 283

15 Radiotherapy Management of Brain Tumors[Khaled M. Alekhteyar and Eli Glatstein] 307

16 Chemotherapy of Brain Tumors[M. Kelly Nicholas and Michael D. Prados] 331

17 Chemotherapy and Pediatric Brain Tumors[Joāo Siffert and Jeffrey C. Allen] 363

18 Chemosensitivity Testing Human Malignant Brain Tumors[John L. Darling. G. M. Lewandowicx, and David G. T. Thomas] 413

19 The Treatment of Barin Tumors with Drug-Impregnated Biodegradable Polymers[Phillip B. Storm and Henry Berm] 435

20 Immunobiology fo Malignant Gliomas[M. Tada and Nicolas de Tribolet] 447

21 Interleukin-2,the Cerebrovasculature, and the Treatment of Malignant Glioma[Randall E. Merechant, Mary D. Ellison, and Carol A. Kruse] 469

22 Cellular Therapy of Brain Tumors: Clinical Trials[Carol A. Kruse] 487

23 Targeted Toxin Therapy[Walter A. Hall] 505

24 Herpes Simplex Gene Therapy Vectors for the Treatment of Cancer[Thomas Oligino, David Krisky, Peggy Marconi, David J. Fink, and Joseph C. Glorioso] 517

25 Genetic Approaches for the Therapy of Malignant Brain Tumors[Edward H. Oldfield and Zvi Ram] 541

Index 553