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Part I PRINCIPLES OF MOLECULAR CARDIOLOGY 1

1 General Principles of Molecular Biology[Nadia Rosenthal] 3

2 Genetic Approaches to Cardiovascular Disease[Reed Edwin Pyeritz] 19

3 Genetically Modified Animal Models in Cardiovascular Research[Stephen G. Young·Aldons J. Lusis·Robert E. Hammer] 37

4 Gene Transfer Approaches for Gardiovascular Disease[Elizabeth Nabel·Jeffrey M. Leiden] 86

Part II MORPHOGENESIS AND CARDIOVASCULAR DISEASES 113

5 Molecular Advances in Cardiovascular Development[Mark C. Fishman·Eric N. Olson·Kenneth R. Chien] 115

6 Molecular Genetics of Congenital Heart Disease [Paul D. Grossfeld·Abraham Rothman·Peter Gruber·Kenneth R. Chien] 135

Part VI PISK FACTORS FOR CORONARY ARTERY DISEASE 141

7 Inherited Vascular Disease[H. C. Dietz·V. A. McKusick] 167

Part III CARDIAC MUSCLE AND MYOPATHIES 189

8 Structure and Function Relationships in Contractile Proteins[Jeffrey Robbins·Leslie A. Leinwand] 191

9 Molecular and Cellular Biology of Cardiac Hypertrophy and Failure[Kenneth R. Chien·Andrew A. Grace·John J. Hunter] 211

10 Molecular Genetics of Inherited Cardiomyopathies[Christine E. Seidman·J. G. Seidman] 251

11 Mitochondrial Genes in Myopathy, Cardiomyopathy, and Stroke[Douglas C. Wallace·Brett Graham] 264

Part IV CARDIAC CONDUCTION AND ARRHYTHMIAS 279

12 Normal Cardiac Electrophysiology[Michael J. Ackerman·David E. Clapham] 281

13 Molecular Basis of Inherited Cardiac Arrhythmias[Mark E. Curran·Michael C. Sanguinetti·Mark T. Keating] 302

14 Molecular Approaches to Arrhythmogenesis[Eduardo Marban] 313

Part V VASCULAR BIOLOGY AND ATHEROGENESIS 329

15 Biology of the Vessel Wall: Endothelium[Michael A. Gimbrone, Jr.·James N. Topper] 331

16 Atherogenesis and Inflammation[Peter Libby·G?ran K. Hansson·Jordan S. Pober] 349

17 Restenosis Injury:A Problem in Regulation of Growth［Thomas F. Deuel·Cesario Bianchi·Lewis Cantley］ 367

18 Angiogenesis in Cardiovascular Disease［Karen S. Moulton·Judah Folkman］ 393

19 Disorders of LipoproteinMetabolism［Alan R. Tall·Marilyn Dammerman·Jon L.Breslow］ 413

20 Lipoprotein Receptiors and Cellular Cholesterol Metabolism in Health and Disease［Ira Tabas·Monty Krieger］ 428

21 Lipoproteins,Lipoprotein Oxidation,and Atherogenesis［Daniel Steinberg·Joseph L.Witztum］ 458

22 Molecular Genetics of Non-Insulin Dependent Diabetes Mellitus［Markus Stoffel］ 477

Part VII MOLECULAR BASIS OF HEMOSTASIS DISORDERS 503

23 Blood Coagulation in Cardiovascular Disease［Kenneth G.Mann·Jay M.Edelberg·Robert D.Rosenberg］ 505

24 The Fibrinolytic System and Thrombolytic Therapy[Désiré Collen·Edgar Haber] 537

25 Platelet Thrombus Formation and Antiplatelet Therapy［Zaverio M.Ruggeri·Garret A.Fitzgerald·Sanford J.shattil］ 566

Part VIII CLOSSARY OF MOLECULAR CENETICS［Kenneth R.Chien·Andrew A.Grace］ 591

lndes 615