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Part I:Principles of Pathology 1

Preface 3

1.Introduction to Pathology 3

Disease 3

Pathology 3

How pathology is covered in this book 3

Acknowledgements 5

2.Cancer 5

Definitions and nomenclature 5

Molecular basis of cancer 7

Dedication 8

Tumour growth 9

Carcinogenic agents 10

Host defences against cancer 13

3.Inflammation, Tissue Damage and Repair 15

Inflammation 15

Acute inflammation 15

Chemical mediators of inflammation 17

Chronic inflammation 19

Tissue necrosis 21

4.Infectious Disease 25

General principles of infection 25

Categories of infectious agents 25

Mechanisms of pathogenicity 29

Inflammatory responses to infection 31

Molecular basis of inherited disease 33

5.Inherited Disease 33

Chromosomal disorders 37

Non-Mendelian inheritance 42

Part II:Systemic Pathology 45

6.Pathology of the Nervous System 47

Disorders of the Central Nervous System 47

Disorders of the Peripheral Nervous System 62

Disorders of the Autonomic Nervous System 67

7.Pathology of the Cardiovascular System 69

Congenital abnormalities of the heart 69

Atherosclerosis, hypertension and ischaemic heart disease 74

Disorders of the heart valves 84

Diseases of the myocardium 90

Diseases of the pericardium 92

Aneurysms 94

Inflammatory and neoplastic vascular disease 97

Diseases of the veins and lymphatics 100

8.Pathology of the Respiratory System 103

Disorders of the Upper Respiratory Tract 103

Disorders of the Lungs 106

Disorders of the Pleura 129

9.Pathology of the Gastrointestinal System 133

Disorders of the upper gastrointestinal tract 133

Disorders of the stomach 139

General aspects of hepatic damage 144

Disorders of the liver and biliary tract 150

Disorders of the exocrine pancreas 163

Disorders of the intestine 166

Disorders ofthe peritoneum 183

10.Pathology of the kidneys and Urinary Tract 187

Abnormalities of kidney structure 187

Diseases of the glomerulus 189

Glomerular lesions in systemic disease 197

Diseases of the tubules and interstitium 199

Diseases ofthe renal blood vessels 202

Neoplastic disease of the kidney 205

Disorders of the urinary tract 206

11.Pathology of the Endocrine System 213

Disorders of the pituitary 213

Thyroid disorders 217

Graves disease 221

Parathyroid disorders 223

Disorders of the adrenal gland 227

Disorders of the endocrine pancreas 231

12.Pathology of the Reproductive Systems 237

Disorders of the vulva, vagina and cervix 237

Disorders of the uterus and endometrium 240

Disorders of the ovary and fallopian tubes 245

Disorders of the placenta and pregnancy 249

Disorders of the breast 253

Disorders of the male reproductive system 255

13.Pathology of the Musculoskeletal System 263

Disorders of the bone structure 263

Infections and trauma 266

Tumours of the bones 269

Disorders of the neuromuscular junction 272

The myopathies 273

Arthropathies 275

14.Pathology of the Blood and Immune System 285

Autoimmune disease 285

Diseases of immune deficiency 290

Amyloidosis 293

Disorders of white blood cells and lymph nodes 295

Disorders of the spleen and thymus 306

Disorders of red blood cells 308

Disorders of haemostasis 320

Terminology of skin pathology 327

15.Pathology of the Skin 327

Inflammation and skin eruptions 329

Infections and infestations 334

Disorders of specific skin structures 342

Disorders of pigmentation 346

Blistering disorders 348

Tumours of the skin 349

Part III:Self-assessment 357

Multiple-choice Questions 359

Short-answer Questions 364

Essay Questions 365

MCQ Answers 366

SAQ Answers 367

Index 371