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INTRODUCTION 1

Ⅰ．STRUCTURE AND ACTIVITY 9

Ⅱ．BIOLOGICAL ASPECTS OF TUMOUR INDUCTION 38

General Characteristics of Tumours 38

Pathology of Induced Tumours 42

Sex Differences and Tumour Induction 51

Age and Tumour Induction 53

Hereditary Differences and Tumour Induction 54

Species Differences and Tumour Induction 59

Influence of the Diet on Tumour Induction 62

Ⅲ．TEST METHODS 68

Mode of Administration 68

Solvent Effects 70

Anti-and Co-carcinogenesis 75

Dosage，Latent Period，Tumour Incidence and the Carcinogenic Index 80

Ⅳ．THEORIES OF THE MODE OF ACTION OF CARCINOGENS 96

Ⅴ．BIOGENETIC RELATIONSHIPS 132

Ⅵ．METABOLISM OF CARCINOGENIC HYDROCARBONS 153

Ⅶ．CARCINOGENIC AZO COMPOUNDS 174

Ⅷ．CARCINOGENIC AROMATIC AMINES AND DERIVATIVES 210

APPENDIX Ⅰ．Some Chemical Carcinogens 222

APPENDIX Ⅱ．Inhibition of Tumour Growth and Possibilities of Tumour Chemotherapy 227

GENERAL REVIEWS 238

INDEX 239

PLATES 42

Ⅰ．Keratinising skin carcinoma in mouse，induced by benzpyrene 42

Ⅱ．Keratinising skin carcinoma in mouse，induced by benzpyrene．A more advanced stage than previous plate 43

Ⅲ．Spindle-celled sarcoma induced in a Strong A mouse by 0．25 mg．methylcholanthrene 44

Ⅳ．Adenocarcinoma of lung induced by methylcholanthrene in a Strong A mouse 45

Ⅴ．Liver of Wistar rat fed dimethylaminoazobenzene with low protein diet for four months．Cholangioma showing a typical formation of new ducts 48