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Ⅰ．CELLULAR UNITS OF HEREDITY 1

The Role of the Nucleus in HeredityGeorge WBeadle 3

Chromosome StructureHans Ris 23

Discussion 62

The Elementary Units of HereditySeymour Benzer 70

Crossing Over and Gene Conversion in NeurosporaHerschel KMitchell 94

Gene Conversion and Problems of AllelismPatricia StLaurence and David MBonner 114

Gene Function and Enzyme FormationSigmund RSuskind 123

Discussion 129

The Role of the Cytoplasm in HeredityDavid LNanney 134

Discussion 164

Ⅱ．ROLE OF THE NUCLEUSNUCLEIC ACIDS AND ASSOCIATED STRUCTURES IN CELL DIVISION AND PROTEIN SYNTHESIS 167

Some Problems in the Chemistry of MitosisDaniel Mazia 169

Some Cytochemical Contributions to Genetic ChemistryMax Alfert 186

Discussion 194

The Nucleus and Protein SynthesisVAllfrey,AEMirsky and SOsawa 200

Nucleic Acids and the Synthesis of ProteinsSSpiegelman 232

Effects of Nucleotides on the Incorporation of Amino Acids into ProteinGeorge CWebster 268

Repression and Induction as Control Mechanisms of Enzyme Biogenesis:TheAdaptiveFormation of AcetylornithinaseHenry JVogel 276

Discussion 290

Ⅲ．NUCLEIC ACIDS AS TRANSFORMING AGENTS 297

X-Ray Inactivation Studies on Solutions of Transforming DNA of PneumococcusHarriett Ephrussi-Taylor 299

Criteria for Quantitative Genetic Transformation of BacteriaRollin DHotchkiss 321

Studies on Transformation of Hemophilus InfluenzaeSol HGoodgal and Roger MHerriott 336

Photoreactivation of Hemophilus Influenzae Transforming Factor for Streptomycin Resistance by an Extract of Escherichia Coli BSol HGoodgalClaud SRupert and Roger MHerriott 341

Discussion 343

Properties of the Transforming PrinciplesStephen Zamenhof 351

Chromatographic Fractionation of EColi DNA Containing 5-Bromouracil-2-C14Aaron Bendich,Herbert BPahl and George Bosworth Brown 378

Discussion 386

Ⅳ．VIRUSES AS BEARERS OF HERITABLE CHARACTERISTICS 397

The Virulent Teven Phages of Escherichia Coli BRoger MHerriott 399

Transduction:A Comparative ReviewPhilip EHartman 408

Discussion 463

Genetic Aspects of LysogenyFrancois Jacob and Elie LWollman 468

Discussion 499

The Nature of the Progeny of Virus Reconstituted from Protein and Nucleic Acid of Different Strains of Tobacco Mosaic VirusHFraenkel-Conrat,Beatrice ASinger and Robley CWilliams 501

Discussion 512

Ⅴ．NUCLEIC ACIDS—CHEMICAL COMPOSITION AND STRUCTURE 519

Base Composition of Deoxypentose and Pentose Nucleic Acids in Various SpeciesErwin Chargaff 521

Discussion 527

The Structure of DNAFHCCrick 532

The Physical Heterogeneity of DNAJAVButler and KVShooter 540

Discussion 543

X-Ray Studies on RNA and the Synthetic PolyribonucleotidesJDWatson 552

The Structure of Synthetic Polyribonucleotides and the Spontaneous Formation of a New Two-Stranded Helical MoleculeAlexander Rich 557

Discussion 562

Importance of Helices in Molecules of Biological OriginBarbara WLow 565

Discussion 575

Ⅵ．SYNTHESIS OF NUCLEOTIDES AND NUCLEIC ACIDS 577

Pathways of Enzymatic Synthesis of Nucleotides and PolynucleotidesArthur Kornberg 579

The Enzymatic Conversion of Deoxyuridylic Acid to Thymidylic Acid and the Participation of Tetrahydrofolic AcidMorris Friedkin and Arthur Kornberg 609

Polynucleotide SynthesisSevero Ochoa and Leon AHeppel 615

The Nature of RNA Labeling in HomogenatesVan RPotter,John HSchneider and Liselotte IHecht 639

Discussion 644

The Biosynthesis of Nucleic Acids in Sonic Microbial SystemsSeymour SCohen 651

RNA Metabolism in T2-Infected Escherichia ColiElliot Volkin and LAstrachan 686

Discussion 695

Ⅶ．MECHANISM OF DUPLICATION 697

On the Mechanism of DNA ReplicationMax Delbruck and Gunther SStent 699

The Molecular Basis of Genetic Recombination in PhageCLevinthal and CAThomasJr 737

Discussion 743

Ⅷ．SUMMARYBentley Glass 757

AUTHOR INDEX OF PARTICIPANTS 837

SUBJECT INDEX 839