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GENERAL CONSIDERATIONS 1

CHAPTER 1．PROPERTIES OF CLINICAL IMPORTANCE AND GENERAL CONSIDERATION OF RESULTS 1

CHAPTER 2．CONDITIONS COMPLICATING TREATMENT 20

TOXIC EFFECTS 20

ALLERGIC OR SENSITIZATION REACTIONS 22

＇THERAPEUTIC SHOCK＇ 35

APPEARANCE OF INSUSCEPTIBLE INFECTION 37

MISCELLANEOUS COMPLICATIONS 44

CHAPTER 3．ADMINISTRATION 47

SYSTEMIC ADMINISTRATION 47

Determination of dosage 48

Duration of treatment 71

Dosage of penicillin X and other penicillins 73

Methods of systemic administration 74

LOCAL ADMINISTRATION 94

Principal routes of application 95

CONCLUSION 117

THE TREATMENT OF DISEASES DUE TO SPECIFIC ORGANISMS 119

CHAPTER 4．GONORRHOEA，CHANCROID，GRANULOMA INGUINALE，AND LYMPHOGRANULOMA VENEREUM 119

GONORRHOEA 119

CHANCROID 135

GRANULOMA INGUINALE 136

LYMPHOGRANULOMA VENEREUM 136

CHAPTER 5．SYPHILIS 137

EXPERIMENTAL INDICATIONS FOR OPTIMAL DOSAGE SCHEMES 137

RESISTANT INFECTION 140

TREATMENT OF EARLY ACQUIRED SYPHILIS 141

TREATMENT OF MATERNAL，PRENATAL，AND CONGENITAL SYPHILIS 159

TREATMENT OF LATE SYPHILIS 169

PROPHYLAXIS AND CONTROL 182

SUMMARY AND CONCLUSIONS 183

CHAPTER 6．HAEMOLYTIC STREPTOCOCCAL (GROUP A) INFECTIONS AND CONDITIONS COMMONLY ASSOCIATED WITH THEM 187

GENERAL CONSIDERATIONS 187

SCARLET FEVER 188

ACUTE STREPTOCOCCAL TONSILLITIS AND NASOPHARYNGITIS 192

RHEUMATIC FEVER 194

PERICARDITIS 196

ACUTE NEPHRITIS 197

CONCLUSIONS 197

CHAPTER 7．INFECTIONS DUE TO OTHER ORGANISMS OF VARYING SUSCEPTIBILITY 198

ACTINOMYCOSIS 198

ANTHRAX 204

DIPHTHERIA AND CARRIERS OF C．diphtheriae 205

CLOSTRIDIAL INFECTIONS 211

Tetanus 211

Gas gangrene and allied conditions 213

MENINGOCOCCAL SEPTICAEMIA 218

TYPHOID FEVER AND TYPHOID CARRIERS 220

BACTERIAL INFECTIONS UNAFFECTED BY PENICILLIN 222

CHAPTER 8．TROPICAL AND RARER NON-BACTERIAL INFECTIONS 224

TROPICAL ULCER，CANCRUM ORIS，AND NOMA 224

PINTA 228

YAWS 228

RELAPSING FEVER 232

PAT-BITE FEVER 233

DISEASES DUE TO LEPTOSPIRAE 235

Weil＇s disease 235

Infection with Leptospira canicola 236

MELIOIDOSIS 237

ERYSIPELOID 238

BARTONELLOSIS 241

RICKETTSIAL DISEASES 243

DISEASES DUE TO VIRUSES 243

Psittacosis and ornithosis 243

Smallpox 245

DISEASES DUE TO PROTOZOA 246

DISEASES DUE TO FUNGI 248

DISEASES OF UNKNOWN AETIOLOGY 250

CHAPTER 9．ENDOCARDITIS AND INFECTIONS OF THE ARTERIES 251

SUBACUTE BACTERIAL ENDOCARDITIS 251

Comparison of recovery rates before and after penicillin 251

Bacteria responsible for infection 252

Histological effect of penicillin 253

Treatment 256

Progress as a result of treatment 265

Prophylaxis 270

ACUTE BACTERIAL ENDOCARDITIS 270

ENDARTERITIS ASSOCIATED WITH CONGENITAL ANOMALIES 272

OTHER DISEASES OF THE ARTERIES 272

CONCLUSION 272

CHAPTER 10．SOFT TISSUE INFECTIONS，BURNS，AND INFECTIONS OF THE HANDS 274

SOFT TISSUE INFECTIONS 274

BURNS 287

PENICILLIN IN PLASTIC SURGERY 294

INFECTIONS OF THE HANDS 299

CHAPTER 11．INFECTIONS OF BONES AND JOINTS 310

ACUTE HAEMATOGENOUS OSTEOMYELITIS 310

ACUTE OSTEOMYELITIS DUE TO LOCAL SPREAD 326

POST-OPERATIVE OR TRAUMATIC OSTEOMYELITIS 329

CHRONIC OSTEOMYELITIS 329

PYOGENIC INFECTION COMPLICATING TUBERCULOUS LESIONS OF BONES AND JOINTS 336

SEPTIC ARTHRITIS 336

RHEUMATOID ARTHRITIS 342

CHAPTER 12．INFECTIONS OF THE CENTRAL NERVOUS SYSTEM 343

LEPTOMENINGITIS 343

PACHYMENINGITIS，SUBDURAL AND EPIDURAL ABSCESS 363

SPINAL ABSCESS 365

BRAIN ABSCESS 365

OSTEOMYELITIS OF THE SKULL AND SPINE 367

PROPHYLACTIC USE OF PENICILLIN IN SURGERY OF THE CENTRAL NERVOUS SYSTEM 367

CAVERNOUS SINUS THROMBOSIS 368

CHAPTER 13．INFECTIONS WITHIN THE THORAX 371

INFECTIONS OF THE LUNGS AND BRONCHI 371

Pneumonia 371

Empyema 388

Lung abscess and suppurative pneumonitis 402

Chronic infections of the bronchi and bronchioles 407

Asthma 414

Other respiratory conditions 416

SUPPURATIVE PERICARDITIS 417

MEDIASTINITIS 419

CHAPTER 14．OTOLARYNGOLOGICAL INFECTIONS AND ORAL SEPSIS 420

OTOLARYNGOLOGICAL INFECTIONS 420

Acute coryza 420

Nasopharyngitis 421

Sinusitis 422

Infections involving the tonsils 427

Acute Laryngitis 429

Acute Laryngo-tracheo-bronchitis 429

Otitis media and mastoiditis 430

Otitis externa 439

Stenosis of the Eustachian tube 439

Ludwig＇s angina 440

Other infections in the neck 440

ORAL SEPSIS 441

Stomatitis and gingivitis 441

Dental infection 443

CHAPTER 15．INFECTIONS OF THE EYE 447

BACTERIOLOGICAL FINDINGS IN EYE INFECTIONS 447

METHODS OF ADMINISTRATION 449

RESULTS OF CLINICAL TRIALS 453

Comparative studies 453

Reactions 455

Infections of the lids and lachrymal apparatus 455

Conjunctivitis 458

Infections of the cornea 461

Gonococcal ophthalmia 465

Ophthalmia neonatorum 467

Trachoma 470

Intraocular inflammation 471

Wounds of the eye 475

Infections of the eye socket 482

Orbital cellulitis 483

CHAPTER 16．DISEASES OF THE SKIN 485

GENERAL CONSIDERATIONS 485

METHODS OF TREATMENT AND RESULTS OF CLINICAL TRIALS 492

CHAPTER 17．INFECTIONS OF THE GENITO-URINARY TRACT 503

BACTERIOLOGICAL CONSIDERATIONS 503

RESULTS OF CLINICAL TRIALS 505

CHAPTER 18．INFECTIONS WITHIN THE ABDOMEN 518

BACTERIOLOGICAL AND EXPERIMENTAL CONSIDERATIONS 518

RESULTS OF CLINICAL TRIALS 520

CHAPTER 19．OBSTETRIC AND GYNAECOLOGICAL CONDITIONS 533

OBSTETRIC CONDITIONS 533

GYNAECOLOGICAL CONDITIONS 544

CHAPTER 20．INFECTIONS IN INFANCY 548

BACTERIOLOGICAL CONSIDERATIONS 548

METHODS OF ADMINISTRATION 549

RESULTS OF CLINICAL TRIALS 555

GENERAL CONSIDERATIONS AND CONCLUSIONS 561

CHAPTER 21．CONDITIONS ASSOCIATED WITH DISTURBANCES OF THE BLOOD 563

CHAPTER 22．BATTLE CASUALTIES 568

THE FIRST RESULTS 568

LATER RESULTS 571

SOFT TISSUE WOUNDS AND FRACTURES 575

WOUNDS OF JOINTS 585

WOUNDS OF THE CHEST 588

HEAD WOUNDS 592

PENICILLIN IN WAR MEDICINE 601

BIBLIOGRAPHY 603

SUBJECT INDEX 677

AUTHOR INDEX 689