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Introduction： There is But One Medicine．＆By WILLIAM D．MALHERBE 467

Part Ⅰ： Some Special Aspects of Metabolic Dyfunction 469

Kinetic Basis of Life Processes： Pathways andMechanisnmofHepatieProtein Synthesis．＆By DAVID L． DR．ABKIN 469

Biochemical Lesions in the Pathogenesis of Geeldikkop （Tribulosis Ovis） and EnzooticIcterus in Sheep in South Africa．＆By J．M．M．BROWN 504

Swine Atherosclerosis： The Relationship of Lipids and Blood Coagulation to Its De-velopnment．＆By H．G．DOWNIE，J．F． MUSTARD AND H．C． ROWSELL 539

Present Concepts Concerning the Origin of Matrix and Stones．＆By WILLIAM H．BOYCE AND J．STANTON KING， JR 563

Part Ⅱ： Metabolic Aspects of Urolithiasis In Man and Animals 579

Immunological Studies on Serum and Urinary Proteins in Urolith Matrix inMan．＆By J． STANTON KING， JR．AND WILLLAM H． BOYCE 579

Silicon Metabolism and Silicon-Protein Matrix Interrelationship in Bovine Urolith-iasis．＆By RICHARD F． KEELER 692

Ion-Competition and the Formation of Phosphatic Uroliths．＆By ROBERT H．UDALLAND Fu Ho CHEN CHOW 612

Renal Calculi Associated with Hyperoxaluria．＆By GEORGE D． LUDWIG 621

Studies on Ovine Urinary Biocolloids and Phosphatic Calculosis．＆By CHARLES E．CORNELIUS 638

Part Ⅲ： The Porphyrias 658

Introduction： Some Historical Highlights in Knowledge of Porphyrins and Por-phyrias．＆By DAVID L． DRABKIN 658

Types of Porphyria： Some Thoughts about Biochemical Mechanisms Involved．＆ByC． RIMINGTON 666

Enzymatic Mechanisms in Porphyrin Synthesis： Possible Enzymatic Blocks in Por-phyries．＆By LAWRENCE BOGORAD 676

Erythrokinetics and Iron Metabolism in Bovine Porphyria Erythropoietica．＆ByJ． J． KANEKO 689

Porphyria In Domestic Animals： Danish Observations in Pigs and Cattle and Com-parison with Human Porphyria．＆By S． K． JφRGENSEN AND TORBEN K．WITH 701

Hyponatremia in Acute Intermittent Porphyria Probably Resulting from Inappro-priate Secretion of Antidiuretic Hormone．＆By GEORGE D． LUDWIG AND MAR-TIN GOLDBERG 710

Part Ⅳ： Ketosis 735

The Biochemistry of Ketosis．＆By RUBIN BRESSLER 735

Hormonal Aspects of Ketosis．＆By FRANK L． ENGEL AND THOMAS T． AMATRUDA， JR 753

Diabetic Ketosis．＆By WALTON W． SHREEVE 772

Fasting Ketosis in the Pregnant Guinea Pig．＆By F． SAUER 787

Ruminant Ketosis： A Speculative Approach．＆By D． S． KRONFELD 799