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PART Ⅰ． EXPERIMENTAL STUDIES IN ANIMALS 1

CHAPTER Ⅰ． DEFINITION AND DESCRIPTION OF EXPERIMENTAL CATATONIA 3

CHAPTER Ⅱ． ADDITIONAL EXPERIMENTS ON BULBOCAPNINE CATATONIA 6

A．Experiments on Symptomatology in Various Animals 6

1．Experimental Bulbocapnine Catatonia in a Chimpanzee 6

2．Acute Bulbocapnine Intoxication in the Dog 8

3．Experimental Bulbocapnine Catatonia in Birds 12

4．Oscillographic Studies of Bulbocapnine Tremor and Catalepsy in Macacus Rhesus 23

5．Emotional Expressions of Cats in Bulbocapnine Catatonia 27

B．Localization Problems of Bulbocapnine Catatonia 33

1．The Central or Peripheral Action of Bulbocapnine 33

2．The Localization of Some Hypokinetic Phenomena of Experimental Bulbocapnine Catatonia 36

3．The Effects of the Injection of Bulbocapnine and of Mescaline upon Cats whose Cerebellum has been ablated in Whole or in Part 40

CHAPTER Ⅲ． EXPERIMENTAL CATATONIA PRODUCED BY INJECTION OF CHEMICAL AND BIOCHEMICAL SUBSTANCES OTHER THAN BULBOCAPNINE 45

1．Cannabis Indica Experiments 45

2．Experiments with Sedative Drugs 48

3．Harmine Experiments 50

4．Experiments with Mescaline in the Mouse，Cat，Monkey，Pigeon and Frog 52

5．Hormonal Experimental Catatonia 57

6．Experimental Catatonia by means of Derivatives of Mescaline and Adrenaline 70

7．Experiments with Substances related to Choline 83

CHAPTER Ⅳ． ASPHYXIATION-CATATONIA，ETC 85

1．Experimental Catatonia Produced by Gases 85

2．The So-Called Interruption of Bulbocapnine Catatonia by means of a Mixture of CO2 and O2 92

3．Catatonic Phenomena Produced by Bilateral Ligation of the Carotid Artery 100

CHAPTER Ⅴ． EXPERIMENTAL CATATONIA INDUCED BY BRAIN LESIONS AND MECHANICAL MEANS 105

1．＂Neurosurgical＂Catatonia 105

2．Experimental Catatonia in Rats produced by Centrifugation 112

CHAPTER Ⅵ． EXPERIMENTAL CATATONIA PRODUCED BY ELECTRICITY，AUDIOGENIC STIMULATION，ETC 123

1．Electronarcosis and Experimental Catatonia 123

2．Experimental Catatonia after Electroshock in Rats 125

3．Experimental Catatonia after Audiogenic Stimulation in Rats，＂Animal Hypnosis＂Etc 126

CHAPTER Ⅶ． EXPERIMENTAL CATATONIA PRODUCED BY ALTERATION OF METABOLIC FUNCTION 129

1．Experimental Catatonia after the Artificial Obstruction of the Lumen of the Intestine 129

2．Experimental Catatonia after Ligation of the Hepatic Artery in Cats 132

3．Experimental Catatonia in Dogs with Partial Elimination of the Liver Function after Applying an Eck＇s Fistula 138

4．Ligation of the Renal Artery and Production of Tissue Necrosis in the Liver，etc 148

5．Ligation of the Splenic artery 150

6．Final Discussion on Catatonic Phenomena produced by Experimental Alteration of Metabolic Function 152

PART Ⅱ． IMPLICATIONS FOR HUMAN PATHOLOGY 155

CHAPTER Ⅰ． THE SIMILARITY OP CATATONIC SYMPTOMS IN MAN AND ANIMALS 157

CHAPTER Ⅱ． CLINICAL SIGNS DERIVED FROM STUDIES ON EXPERIMENTAL CATATONIA 161

CHAPTER Ⅲ． EXPERIMENTAL CATATONIA BY MEANS OF LIPOID SOLUBLE AND OTHER SUBSTANCES OF HUMAN URINE FROM NORMAL AND PATHOLOGICAL INDIVIDUALS 166

1．Experiments on the Lipoid Soluble Substances in the Human Urine Capable of Producing Signs of Experimental Catatonia in Mice and Rats 166

2．The Identification of ＂Catatonine＂ 170

3．Pharmacological Standardization of Nicotine in Rats and Mice 172

4．The Production of Experimental Catatonia by the Injection of Urinary Extracts derived from a Nicotine-free Schizophrenic Patient 174

5．The Improvement of the Method of Obtaining Neurotoxins from Human Urine 176

6．Neurotoxic，especially Catatonic Symptoms，produced in Mice by Substances from Human Urine 187

7．Signs of Experimental Catatonia produced by Indolethylamine 195

8．The Action of Dimethylguanidine Chloride on Motility 197

CHAPTER Ⅳ． QUANTITATIVE DETERMINATION OF HISTAMINE IN THE BLOOD OF NORMAL INDIVIDUALS AND SCHIZOPHRENICS 203

CHAPTER Ⅴ． THE CEPHALIN-CHOLESTEROL FLOCCULATION BLOOD TEST IN CATATONIC AND OTHER SCHIZOPHRENICS 210

CHAPTER Ⅵ． GENERAL SUMMARY AND CONCLUSIONS 221